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Wire

Sector Update: Healthcare Stocks Decline Late Afternoon

Healthcare stocks declined late Thursday afternoon, with the NYSE Healthcare Index shedding 1.5% and the State Street Health Care Select Sector SPDR ETF (XLV) falling 1.7%.The iShares Biotechnology ETF (IBB) was up 0.3%.In corporate news, Xencor (XNCR) shares rose nearly 11% after the company said it has reached a settlement agreement with AstraZeneca (AZN) subsidiary Alexion Pharma International to resolve a commercial dispute over US royalties on Ultomiris. AstraZeneca shares were down 1.2%.Eli Lilly (LLY) expanded its collaboration with Resilience to invest $750 million as part of its effort to boost US production of Lilly's KwikPen injectable device for diabetes and obesity medicines, Resilience said Thursday. Lilly shares were down 4.4%.Johnson & Johnson (JNJ) said it has entered into strategic agreements with Sail Biomedicines to advance the biotech's in vivo CAR-T therapy platform for immune-mediated diseases, including an equity investment and an exclusive option to buy Sail for $2.58 billion. Johnson & Johnson shares fell 3.8%.Bausch Health (BHC) shares surged 26% after it reported higher Q2 results and raised its 2026 revenue outlook.Regeneron Pharmaceuticals (REGN) shares were up 6.3% after it reported higher Q2 results.

$AZN$BHC$JNJ$LLY$REGN$XNCR
Sectors

Sector Update: Healthcare

Healthcare stocks declined late Thursday afternoon, with the NYSE Healthcare Index and the State Street Health Care Select Sector SPDR ETF (XLV) each shedding 1.5%.The iShares Biotechnology ETF (IBB) was up 0.3%.In corporate news, Xencor (XNCR) shares rose 11% after the company said it has reached a settlement agreement with AstraZeneca (AZN) subsidiary Alexion Pharma International to resolve a commercial dispute over US royalties on Ultomiris. AstraZeneca shares were down 1%.

$AZN$XNCR
Wire

Xencor Shares Rise After Settlement Deal With Alexion

Xencor (XNCR) shares were up about 10% in Thursday trading after the company said it has reached a settlement agreement with Astrazeneca (AZN) subsidiary, Alexion Pharma International, to resolve a commercial dispute over US royalties on Ultomiris.Xencor said it will receive $105 million in two equal payments following the settlement, adding that Alexion will no longer have to pay royalties on US sales of the drug.The company said it expects to continue receiving royalties on sales outside the US.Xencor added that it expects to have sufficient cash resources to fund programs and operations through 2028.Price: $21.56, Change: $+2.03, Percent Change: +10.39%

$AZN$XNCR
Sectors

Sector Update: Healthcare Stocks Advance Late Afternoon

Healthcare stocks were higher late Monday afternoon, with the NYSE Healthcare Index rising 0.6% and the State Street Health Care Select Sector SPDR ETF (XLV) adding 0.8%.The iShares Biotechnology ETF (IBB) advanced 0.7%.In corporate news, Forte Biosciences (FBRX) shares soared 39% after it agreed to be acquired by Argenx (ARGX) in a deal worth about $2.2 billion. Argenx shares were down 2.5%.AstraZeneca (AZN) shares were up 0.8% after it posted higher Q2 core earnings and revenue, and raised its interim dividend.Ensign (ENSG) shares climbed nearly 3% after it reported higher Q2 adjusted earnings and revenue, and raised its 2026 outlook.Veru (VERU) said Monday it has completed enrollment in a phase 2 trial evaluating its experimental drug enobosam in combination with semaglutide, in about 200 adults aged 65 and older with obesity. Veru shares gained 3.1%.

$ARGX$AZN$ENSG$FBRX$VERU
Sectors

Sector Update: Healthcare Stocks Advance Monday Afternoon

Healthcare stocks were higher Monday afternoon, with the NYSE Healthcare Index rising 0.8% and the State Street Health Care Select Sector SPDR ETF (XLV) adding 0.9%.The iShares Biotechnology ETF (IBB) advanced 0.5%.In corporate news, Forte Biosciences (FBRX) shares soared 39% after it agreed to be acquired by Argenx (ARGX) in a deal worth about $2.2 billion. Argenx shares were down 2.2%.AstraZeneca (AZN) shares were up marginally after it posted higher Q2 core earnings and revenue, and raised its interim dividend.Ensign (ENSG) shares climbed 4% after it reported higher Q2 adjusted earnings and revenue, and raised its 2026 outlook.

$ARGX$AZN$ENSG$FBRX
Wire

Top Midday Stories: Nvidia Enters Into $500 Billion Partnership With SK Group; AstraZeneca Earnings Top Estimates

The Dow Jones Industrial Average was up, while the S&P 500 and Nasdaq Composite were down in late-morning trading Monday, as oil prices fell amid a pause in the hostilities between US and Iran over the weekend.In company news, Nvidia (NVDA) has agreed to expand its partnership with South Korean conglomerate SK Group with a more than $500 billion artificial intelligence infrastructure initiative. The deal announced Saturday includes a long-term partnership between Nvidia and SK Hynix (SKHY) that will provide the US technology giant a stable supply of next-generation AI memory. They will also jointly co-develop next-generation AI memory solutions that include high-bandwidth memory chips intended for AI training, AI agents and physical AI applications. Nvidia shares were down 5.1% around midday, while SK Hynix shares were down 8.8%.Further, Nvidia is in talks to provide a roughly $250 billion financial backstop for Microsoft (MSFT)-backed OpenAI as part of a massive data center project in southern Ohio that could cost more than $500 billion, The Wall Street Journal reported Sunday, citing unnamed sources familiar with the matter. The guarantees would help OpenAI secure financing to lease a 10-gigawatt campus being developed by SoftBank-owned SB Energy. Nvidia is also discussing financing for up to $350 billion in AI chip purchases, according to the report.AstraZeneca (AZN) reported Q2 core earnings Monday of $2.63 per diluted share, up from $2.17 a year earlier and above the FactSet consensus analyst estimate of $2.49. Q2 revenue was $15.38 billion, up from $14.46 billion a year ago and below the FactSet consensus of $15.43 billion. For 2026, the company continues to expect core EPS to rise by a low double-digit percentage and revenue to grow by a mid-to-high single-digit percentage. Analysts are looking for $10.24 and $63.18 billion, respectively. The company also raised its interim dividend by 3 cents to $1.06 per share. AstraZeneca shares were up 1.2%.United Airlines (UAL) pitched a merger deal to Delta Air Lines (DAL) last year, but the talks fizzled out without a deal after Delta declined to pursue the proposal, The Wall Street Journal reported Sunday, citing sources familiar with the matter. Sources told the news outlet that discussions reached preliminary due diligence, where Delta Air Lines management assessed the potential merger. The proposal came before President Donald Trump's return to office, when companies anticipated a more favorable regulatory backdrop for major mergers, according to the report. United Airlines shares were up 1%, while Delta Air Lines shares were up 1.5%.Baker Hughes (BKR) reported Q2 adjusted earnings Sunday of $0.64 per diluted share, up from $0.63 a year earlier and above the FactSet consensus analyst estimate of $0.49. Q2 revenue was $6.74 billion, down from $6.91 billion a year ago and above the FactSet consensus of $6.51 billion. Baker Hughes also maintained its quarterly dividend at $0.23 per share, payable on Aug. 17 to holders of record on Aug. 7. Further, the company said that its total orders stood at $10.50 billion in Q2, a 49% jump from $7.03 billion a year earlier, as orders under the industrial and energy technology segment doubled. Segment orders in the quarter surged year over year to $7.09 billion from $3.53 billion, led by the gas technology product line. Segment revenue also steadied at $3.29 billion, data showed. Baker Hughes shares were up 5.8%.DeepSeek has suspended its second fundraising round after informing some prospective investors that investment agreements would not be signed as expected, Bloomberg reported Saturday, citing people familiar with the matter. The pause followed viral online posts widely attributed to founder Liang Wenfeng about US-China artificial intelligence competition. Bloomberg could not verify the authenticity of the posts. DeepSeek had been seeking to raise at least 10 billion yuan at a pre-money valuation of at least 480 billion yuan and is preparing for an initial public offering that could be filed as early as this year, according to the report.Price: $196.23, Change: $-10.61, Percent Change: -5.13%

$AZN$BKR$DAL$MSFT$NVDA$SKHY$UAL
Sectors

Sector Update: Healthcare Stocks Edge Higher Premarket Monday

Healthcare stocks were edging higher premarket Monday, with the State Street Health Care Select Sector SPDR ETF (XLV) up 0.4% and the iShares Biotechnology ETF (IBB) advancing by 0.5%.AstraZeneca (AZN) stock was up 0.8% after the company posted higher Q2 core earnings and revenue, and raised its interim dividend.Ensign Group (ENSG) shares were up nearly 11% after the company reported higher Q2 adjusted earnings and revenue, and raised its 2026 outlook.Argenx (ARGX) has agreed to buy Forte Biosciences (FBRX) for $77 per share in cash. Shares of Forte Biosciences were up more than 39% pre-bell.

$ARGX$AZN$ENSG$FBRX$IBB$XLV
Commodities

Exchange-Traded Funds, Equity Futures Higher Pre-Bell Monday as Oil Prices Fall

The broad market exchange-traded fund SPDR S&P 500 ETF Trust (SPY) was up 0.9%, and the actively traded Invesco QQQ Trust (QQQ) advanced 1.4% in Monday's premarket activity, as oil prices fell amid hopes of a US-Iran truce.US stock futures were also higher, with S&P 500 Index futures up 0.9%, Dow Jones Industrial Average futures advancing 1.2%, and Nasdaq futures gaining 1.4% before the start of regular trading.New orders for US durable goods rose by 0.3% in June following a decline of 4.0% in May, compared with the expectations for a larger increase of 1.8% in a survey compiled by Bloomberg.The Dallas Federal Reserve's manufacturing index for July will be released at 10:30 am ET.In premarket action, bitcoin was up by 0.6%. Among cryptocurrency ETFs, the cryptocurrency fund ProShares Bitcoin Strategy ETF (BITO) was 1.5% higher, Ether ETF (EETH) rose 5.4%, and Bitcoin & Ether Market Cap Weight ETF (BETH) retreated marginally by 0.01%.Power Play:EnergyThe iShares US Energy ETF (IYE) declined by 2.1%, while the State Street Energy Select Sector SPDR ETF (XLE) fell 2.6%.TotalEnergies (TTE) stock was down more than 3% before market open after the company said it has decided to appeal a June 25 ruling by the Paris Judicial Court in a climate-related duty-of-vigilance case.Winners and Losers:IndustrialThe State Street Industrial Select Sector SPDR ETF (XLI) advanced 0.9%, the Vanguard Industrials Index Fund (VIS) gained 0.8%, and the iShares US Industrials ETF (IYJ) was 0.3% higher.United Airlines (UAL) stock was up more than 3%, while Delta Air Lines (DAL) shares rose 2.7% before the opening bell, a day after The Wall Street Journal reported that United pitched a merger deal to Delta last year, but the talks fizzled out without a deal after Delta declined to pursue the proposal.FinancialThe State Street Financial Select Sector SPDR ETF (XLF) advanced 0.8%. Direxion Daily Financial Bull 3X Shares (FAS) was up 1.8%, while its bearish counterpart, Direxion Daily Financial Bear 3X Shares (FAZ), was 2.2% lower.Northern Trust (NTRS) shares traded up 2% in early hours activity after the company said it has been selected to provide fund administration and related services to alternative asset manager Dawson Partners.TechnologyThe State Street Technology Select Sector SPDR ETF (XLK) advanced 1.6%, the iShares US Technology ETF (IYW) was 1.6% higher, and the iShares Expanded Tech Sector ETF (IGM) was up 0.2%. Among semiconductor ETFs, the State Street SPDR S&P Semiconductor ETF (XSD) gained 2.6%, while the iShares Semiconductor ETF (SOXX) rose by 2.2%.Broadcom (AVGO) shares were up more than 2% in premarket activity after the company and Samsung Electronics said they signed a memorandum of understanding to expand their strategic collaboration across memory and foundry technologies to support next-generation artificial intelligence infrastructure.Health CareThe State Street Health Care Select Sector SPDR ETF (XLV) advanced 0.6%, the Vanguard Health Care Index Fund (VHT) was up 1.6%, while the iShares US Healthcare ETF (IYH) slipped 0.01%. The iShares Biotechnology ETF (IBB) was 0.5% higher.AstraZeneca (AZN) stock was up 1% premarket after the company reported higher Q2 core earnings and revenue.ConsumerThe State Street Consumer Staples Select Sector SPDR ETF (XLP) was up 0.1%, the Vanguard Consumer Staples Index Fund ETF Shares (VDC) advanced 0.1%, and the iShares US Consumer Staples ETF (IYK) was inactive. The State Street Consumer Discretionary Select Sector SPDR ETF (XLY) rose 1.1%. The VanEck Retail ETF (RTH) was inactive, while the State Street SPDR S&P Retail ETF (XRT) was 1.2% higher.Toyota Motor (TM) shares were up more than 1% pre-bell after the company said it signed a binding agreement with Volvo Group and Daimler Truck to acquire a one-third stake in fuel-cell joint venture cellcentric.CommoditiesFront-month US West Texas Intermediate crude oil declined by 5.7% to $84.24 per barrel on the New York Mercantile Exchange. Natural gas was down by 3.1% to $2.80 per 1 million British Thermal Units. The United States Oil Fund (USO) was down 6.2%, while the United States Natural Gas Fund (UNG) was 3.7% lower.Gold futures for November gained 0.7% to $4,156.50 an ounce on the Comex. Silver futures were up 0.8% to $59.35 an ounce. SPDR Gold Shares (GLD) increased 0.7%, and the iShares Silver Trust (SLV) was 1.3% higher.

Dow JonesNasdaq CompositeS&P 500$AVGO$AZN$BETH$BITO$DAL$EEM$EETH$EXI$FAS$FAZ$GLD$IBB$IGM$IGV$IPK$IVV$IWM$IYE$IYH$IYJ$IYK$IYW$NTRS$PMR$QQQ$RTH$SLV$SOXX$SPY$TM$TTE$UAL$UNG$USO$VDC$VHT$VIS$XLE$XLF$XLI$XLK$XLP$XLV$XLY$XRT$XSD
Sectors

Sector Update: Healthcare

Healthcare stocks were edging higher premarket Monday, with the State Street Health Care Select Sector SPDR ETF (XLV) and iShares Biotechnology ETF (IBB) advancing by 0.5%.AstraZeneca (AZN) stock was up more than 1% after the company posted higher Q2 core earnings and revenue, and raised its interim dividend.

$AZN
Japan

Update: US Equity Futures Rise Pre-Bell as Oil Prices Drop Amid Pause in Middle East Hostilities

US equity futures rose pre-bell Monday as oil prices declined amid a pause in hostilities between the US and Iran over the weekend.Dow Jones Industrial Average futures were 1.1% higher, S&P 500 futures were up 0.8%, and Nasdaq futures were 1.3% higher.The US did not strike any Iranian targets on Saturday or Sunday after 13 consecutive nights of attacks. The US ambassador to the United Nations, Mike Waltz, told Fox News that President Donald Trump has halted the attacks for the meantime to allow more time for diplomacy. Iran said it will suspend its own attacks as long as the US does the same, Reuters reported Sunday, citing a senior Iranian official.Traders anticipate another round of earnings this week, kicked off by AstraZeneca (AZN), which posted higher Q2 core earnings and revenue.Microsoft (MSFT), Meta Platforms (META), Apple (AAPL), Amazon.com (AMZN), Lam Research (LRCX), and Arm (ARM) are set to release their financial results this week. Anticipated earnings also include Seagate Technology (STX), Qualcomm (QCOM), Procter & Gamble (PG), Visa (V), and Mastercard (MA).Traders also look forward to the Federal Reserve's policy session and rate statement, slated for Wednesday.Oil prices were lower, with front-month global benchmark North Sea Brent crude down 5.2% at $86.94 per barrel and US West Texas Intermediate crude 6% lower at $83.97 per barrel.Durable goods new orders rose 0.3% in June after a 4.0% decline in the prior month, compared with expectations for a 1.8% increase in a survey compiled by Bloomberg. The Dallas Fed manufacturing survey for July will be released at 10:30 am ET.In other world markets, Japan's Nikkei closed 0.5% higher, Hong Kong's Hang Seng ended 1% higher, and China's Shanghai Composite finished 1.2% higher. Meanwhile, the UK's FTSE 100 was up 0.4%, and Germany's DAX index was 1.6% higher in Europe's early afternoon session.In equities, energy-related stocks were on the downswing due to the drop in oil prices. Exxon Mobil (XOM) shares fell 3.4%, Chevron (CVX) stocks were down 2.7%, and Shell (SHEL) shares were 2.3% lower.On the winning side, Broadcom (AVGO) stock was up 2.1% after the company and Samsung Electronics said they signed a memorandum of understanding to expand their strategic collaboration across memory and foundry technologies to support next-generation artificial intelligence infrastructure. Advanced Micro Devices (AMD) shares rose 2.2% after a Korea Times report cited the Ministry of Science and ICT as saying that the company partnered with South Korea to establish an artificial intelligence research facility and expand computing infrastructure. Toyota Motor (TM) stock was up 1.6% after the company said it signed a binding agreement with Volvo Group and Daimler Truck to acquire a one-third stake in fuel-cell joint venture Cellcentric.

Dow JonesNasdaq CompositeS&P 500$AAPL$AMD$AMZN$ARM$AVGO$AZN$CVX$LRCX$MA$META$MSFT$PG$QCOM$SHEL$STX$TM$V$XOM
Stocks Rise Pre-Bell as US, Iran Pause Strikes; Fed Policy Decision, Inflation Report on Deck
US Markets

Stocks Rise Pre-Bell as US, Iran Pause Strikes; Fed Policy Decision, Inflation Report on Deck

The benchmark US stock measures were pointing higher before the opening bell Monday after the US and Iran halted strikes over the weekend, while traders gear up for a busy week that includes a major policy decision by the Federal Reserve, a key inflation report and earnings.The S&P 500 and the Dow Jones Industrial Average rose 0.8% each in premarket activity, while the Nasdaq increased 1.4%. The S&P 500 and the Dow finished Friday's trading session in the green, while the Nasdaq closed lower.After 13 consecutive nights of strikes against Iran, no US attacks against Tehran were officially announced over the weekend. Iran said it will also halt its attacks as long as the US does the same, a senior Iranian official told Reuters on Sunday.West Texas Intermediate crude oil dropped 6.4% to $83.56 a barrel before the open, while Brent fell 8% to $89.06.The US ambassador to the United Nations Mike Waltz reportedly told Fox News on Sunday that President Donald Trump has paused strikes against Iran to give talks "some space."Iranian Foreign Ministry spokesman Esmail Baghaei said technical talks with Oman on the Strait of Hormuz continued over the weekend, CNBC reported.Meanwhile, Iran summoned Ukraine's charge d'affaires in Tehran on Sunday over an attack on an Iranian commercial vessel in the Caspian Sea, calling it a "hostile and criminal act," according to a separate CNBC report.The Fed's monetary policy committee is scheduled to meet on Tuesday, with a decision on interest rates due the following day. The probability the central bank will leave its benchmark lending rate unchanged currently stands at 69%, with the remaining odds in favor of a quarter-percentage-point increase, according to the CME FedWatch tool.Traders also await the personal income and outlays report for June later in the week. The report includes the personal consumption expenditure core price index, the Fed's preferred inflation metric.Treasury yields were down in premarket action, with the two-year rate retreating 2.6 basis points to 4.31% and the 10-year rate off 3.8 basis points to 5.12%.Monday's economic calendar has the durable goods orders report for last month at 8:30 am ET, followed by the Dallas Fed manufacturing survey for July at 10:30 am.Tech giants Microsoft (MSFT), Apple (AAPL), Amazon (AMZN) and Meta Platforms (META) are scheduled to release their latest financial results later this week, along with Visa (V), Mastercard (MA), ExxonMobil (XOM), Coca Cola (KO), Procter & Gamble (PG), Qualcomm (QCOM) and Boeing (BA).Shares of Forte Biosciences (FBRX) jumped 39% pre-bell after it agreed to be acquired by Belgian-Dutch immunology firm argenx (ARGX) in a deal worth roughly $2.2 billion. AstraZeneca's (AZN) US-listed stock gained 1.4% after the company reported its latest quarterly results.Gold inclined 0.7% to $4,098 per troy ounce, while bitcoin advanced 1.1% to $65,350.

Dow JonesNasdaq CompositeS&P 500$AAPL$AMZN$ARGX$AZN$BA$FBRX$KO$MA$META$MSFT$PG$QCOM$V$XOM
Japan

US Equity Futures Rise Pre-Bell as Oil Prices Drop Amid Pause in Middle East Hostilities

US equity futures rose pre-bell Monday as oil prices declined amid a pause in hostilities between the US and Iran over the weekend.Dow Jones Industrial Average futures were 1.1% higher, S&P 500 futures were up 0.9%, and Nasdaq futures were 1.4% higher.The US did not strike any Iranian targets on Saturday or Sunday after 13 consecutive nights of attacks. The US ambassador to the United Nations, Mike Waltz, told Fox News that President Donald Trump has halted the attacks for the meantime to allow more time for diplomacy. Iran said it will suspend its own attacks as long as the US does the same, Reuters reported Sunday, citing a senior Iranian official.Traders anticipate another round of earnings this week, kicked off by AstraZeneca (AZN), which posted higher Q2 core earnings and revenue.Microsoft (MSFT), Meta Platforms (META), Apple (AAPL), Amazon.com (AMZN), Lam Research (LRCX), and Arm (ARM) are set to release their financial results this week. Anticipated earnings also include Seagate Technology (STX), Qualcomm (QCOM), Procter & Gamble (PG), Visa (V), and Mastercard (MA).Traders also look forward to the Federal Reserve's policy session and rate statement, slated for Wednesday.Oil prices were lower, with front-month global benchmark North Sea Brent crude down 6.5% at $85.74 per barrel and US West Texas Intermediate crude 6.8% lower at $83.23 per barrel.The June durable goods orders report is expected to show a 1.8% increase after a decline of 4.5% in the prior month, according to estimates compiled by Bloomberg. The Dallas Fed manufacturing survey for July will be released at 10:30 am ET.

Dow JonesNasdaq CompositeS&P 500$AAPL$AMZN$ARM$AZN$LRCX$MA$META$MSFT$PG$QCOM$STX$V
Asia Markets

Exchange-Traded Funds, Equity Futures Lower Pre-Bell Thursday Amid Major Tech Stocks Sell-Off

The broad market exchange-traded fund SPDR S&P 500 ETF Trust (SPY) was down 0.6%, and the actively traded Invesco QQQ Trust (QQQ) retreated 0.9% in Thursday's premarket activity, as a selloff in major technology stocks follows corporate earnings.US stock futures were also lower, with S&P 500 Index futures down 0.3%, Dow Jones Industrial Average futures slipping 0.3%, and Nasdaq futures retreating 0.3% before the start of regular trading.US initial jobless claims decreased to a level of 187,000 in the employment survey week ended July 18, the lowest level since 1969, from an upwardly revised 209,000 level in the previous week, compared with expectations for an increase to 210,000 in a survey of analysts compiled by Bloomberg.Weekly natural gas stocks are due to be released at 10:30 am ET, followed by the Kansas City Fed's manufacturing index for July at 11:00 am ET.In premarket action, bitcoin was down by 0.7%. Among cryptocurrency ETFs, the cryptocurrency fund ProShares Bitcoin Strategy ETF (BITO) was 0.9% lower, Ether ETF (EETH) retreated 0.04%, and Bitcoin & Ether Market Cap Weight ETF (BETH) declined by 0.02.Power Play:TechnologyThe State Street Technology Select Sector SPDR ETF (XLK) retreated 0.7%, the iShares US Technology ETF (IYW) was 1.1% lower, and the iShares Expanded Tech Sector ETF (IGM) was down 0.4%. Among semiconductor ETFs, the State Street SPDR S&P Semiconductor ETF (XSD) was up 0.1%, while the iShares Semiconductor ETF (SOXX) fell by 1.9%.STMicroelectronics (STM) shares were down more than 13% in premarket activity even after the company reported higher Q2 non-GAAP earnings and revenue.Winners and Losers:ConsumerThe State Street Consumer Staples Select Sector SPDR ETF (XLP) was down 0.4%, the Vanguard Consumer Staples Index Fund ETF Shares (VDC) was up 1.3%, and the iShares US Consumer Staples ETF (IYK) was inactive. The State Street Consumer Discretionary Select Sector SPDR ETF (XLY) lost 1.8%. The VanEck Retail ETF (RTH) was inactive, while the State Street SPDR S&P Retail ETF (XRT) was 1.2% lower.Tesla (TSLA) shares fell more than 7% pre-bell after the electric vehicle manufacturer reported an unexpected year-over-year decline in its Q2 earnings, weighed down by higher operating expenses related to research and development and artificial intelligence initiatives.FinancialThe State Street Financial Select Sector SPDR ETF (XLF) was down 0.3%. Direxion Daily Financial Bull 3X Shares (FAS) was down 0.7%, while its bearish counterpart, Direxion Daily Financial Bear 3X Shares (FAZ), was 0.4% higher.Ameriprise Financial (AMP) shares traded up 2% in early-hours activity after the company reported higher Q2 adjusted earnings and revenue.EnergyThe iShares US Energy ETF (IYE) rose 1.2%, while the State Street Energy Select Sector SPDR ETF (XLE) was up by 1.8%.TotalEnergies (TTE) stock was up more than 2% before market open after the company reported higher Q2 adjusted earnings and revenue.IndustrialThe State Street Industrial Select Sector SPDR ETF (XLI) advanced 0.1%, the Vanguard Industrials Index Fund (VIS) was 0.04% lower, and the iShares US Industrials ETF (IYJ) was up 1%.Union Pacific Railroad (UNP) and Canadian National Railway (CNI) shares rose more than 1% before the opening bell after the companies signed a binding memorandum of understanding establishing a framework for CN to secure competitive access in connection with the proposed merger between Union Pacific and Norfolk Southern (NSC). Norfolk Southern shares were 0.7% lower.Health CareThe State Street Health Care Select Sector SPDR ETF (XLV) advanced 0.2%, the Vanguard Health Care Index Fund (VHT) was up 0.1%, while the iShares US Healthcare ETF (IYH) slipped 0.4%. The iShares Biotechnology ETF (IBB) was 0.1% lower.AstraZeneca (AZN) stock was down more than 1% premarket following a 0.2% gain at the prior close. The company said that the European Commission approved its experimental drug, Etcamah, in combination with a CDK4/6 inhibitor, for adults with a type of breast cancer harboring an ESR1 mutation that emerges during first-line endocrine therapy, after the Phase 3 SERENA-6 trial met its primary endpoint.CommoditiesFront-month US West Texas Intermediate crude oil advanced by 4.3% to $90.56 per barrel on the New York Mercantile Exchange. Natural gas was up by 1.1% to $2.96 per 1 million British Thermal Units. The United States Oil Fund (USO) was up 4.8%, while the United States Natural Gas Fund (UNG) was 1.8% higher.Gold futures for July retreated 1.5% to $4,087.80 an ounce on the Comex. Silver futures were down 2.5% to $58.81 an ounce. SPDR Gold Shares (GLD) decreased 1.7%, and the iShares Silver Trust (SLV) was 3% lower.

Dow JonesNasdaq CompositeS&P 500$AMP$AZN$BETH$BITO$CNI$EEM$EETH$EXI$FAS$FAZ$GLD$IBB$IGM$IGV$IPK$IVV$IWM$IYE$IYH$IYJ$IYK$IYW$NSC$PMR$QQQ$RTH$SLV$SOXX$SPY$STM$TSLA$TTE$UNG$UNP$USO$VDC$VHT$VIS$XLE$XLF$XLI$XLK$XLP$XLV$XLY$XRT$XSD
Sectors

Sector Update: Healthcare Stocks Edge Higher Premarket Wednesday

Healthcare stocks were edging higher premarket Wednesday, with the State Street Health Care Select Sector SPDR ETF (XLV) up 0.3% and the iShares Biotechnology ETF (IBB) marginally advancing.Repligen (RGEN) has agreed to acquire BioLife Solutions (BLFS) in a deal valued at $1.5 billion, the companies said. Shares of Repligen were down more than 4% and BioLife Solutions stock was up more than 2% pre-bell.Royalty Pharma (RPRX) said it will pay up to $425 million, including a $125 million upfront payment, to Neurimmune for a 3% to 4% royalty on worldwide net sales of its interest in AstraZeneca's (AZN) cliramitug. Royalty Pharma stock was down more than 1% pre-bell.Healthcare Services Group (HCSG) shares were 0.8% higher after the company reported that it swung to a Q2 net income as revenue increased during the period.

$AZN$BLFS$HCSG$IBB$RGEN$RPRX$XLV
Asia Markets

European Equities Traded in US as ADRs Decline

European equities traded in the US as American depositary receipts fell in Monday trading with the S&P Europe Select ADR Index shedding 0.6% to 1,894.81.From continental Europe, the gainers were led by technology company Ericsson (ERIC) and healthcare company Fresenius Medical Care (FMS), which rose 2% and 1.6%, respectively. They were followed by software company SAP (SAP), which added 1.4%.The decliners from continental Europe were led by semiconductor company Sequans Communications (SQNS) and tech company Opera (OPRA), which fell 4.4% and 1.4%, respectively.From the UK and Ireland, the gainers were led by telecom giant Vodafone (VOD) and education group Pearson (PSO), which gained 4% and 3.2%, respectively. They were followed by energy giants BP (BP) and Shell (SHEL), which added 2.8% and 1.3%, respectively.The decliners from the UK and Ireland were led by banking group Lloyds (LYG) and pharmaceutical company AstraZeneca (AZN), which shed 1.7% and 1.1%, respectively.

$AZN$BP$ERIC$FMS$LYG$OPRA$PSO$SAP$SHEL$SQNS$VOD
Wire

Update: Market Chatter: AstraZeneca Wins Pfizer Patent Battle Over Cancer Drug

(Updates with AstraZeneca declining to comment in paragraph three).AstraZeneca (AZN) won a lawsuit filed in 2021 by Pfizer (PFE) after a US appeals court upheld a ruling in favor of the drugmaker over allegations that its lung-cancer drug Tagrisso infringed patents, Reuters reported Thursday.The Washington-based US Court of Appeals for the Federal Circuit agreed with a Delaware federal judge that the two patents at the center of the dispute, owned by Pfizer's subsidiary Wyeth, were invalid.AstraZeneca declined to comment, while Pfizer did not immediately respond to' request for comment.AstraZeneca shares were down more than 5% in recent afternoon trading.(Market Chatter news is derived from conversations with market professionals globally. This information is believed to be from reliable sources but may include rumor and speculation. Accuracy is not guaranteed.)Price: $178.88, Change: $-10.41, Percent Change: -5.50%

$AZN$PFE
Sectors

Sector Update: Healthcare Stocks Softer Late Afternoon

Healthcare stocks were lower late Thursday afternoon, with the NYSE Healthcare Index shedding 0.5% and the State Street Health Care Select Sector SPDR ETF (XLV) down 0.4%.The iShares Biotechnology ETF (IBB) increased 0.3%.In corporate news, AstraZeneca (AZN) and its partner Ionis Pharmaceuticals (IONS) said Thursday that a phase 3 trial for eplontersen in people with transthyretin-mediated amyloid cardiomyopathy did not meet the primary efficacy endpoint. AstraZeneca shares fell 5%, and Ionis tumbled 23%.Qiagen (QGEN) is attracting early takeover interest from private equity firms, including EQT AB, Advent and KKR (KKR), with some potential bidders considering offers of at least $50 per share, Bloomberg reported. Qiagen shares jumped 10%.Fate Therapeutics (FATE) shares rose past 5% after the US Food and Drug Administration approved the company's investigational new drug application for FT839, a product candidate to treat autoimmune diseases.MetaVia (MTVA) shares climbed 11% after it said Thursday that all active patients in part 3 of its phase 1 trial for obesity drug candidate DA-1726 have completed dose titration and reached their highest planned doses of 48 mg and 64 mg.

$AZN$FATE$IONS$MTVA$QGEN
Wire

Market Chatter: AstraZeneca Wins Pfizer Patent Battle Over Cancer Drug

AstraZeneca (AZN) won a lawsuit filed in 2021 by Pfizer (PFE) after a US appeals court upheld a ruling in favor of the drugmaker over allegations that its lung-cancer drug Tagrisso infringed patents, Reuters reported Thursday.The Washington-based US Court of Appeals for the Federal Circuit agreed with a Delaware federal judge that the two patents at the center of the dispute, owned by Pfizer's subsidiary Wyeth, were invalid.AstraZeneca and Pfizer did not immediately respond to' request for comment.AstraZeneca shares were down more than 5% in recent afternoon trading.(Market Chatter news is derived from conversations with market professionals globally. This information is believed to be from reliable sources but may include rumor and speculation. Accuracy is not guaranteed.)Price: $179.49, Change: $-9.79, Percent Change: -5.17%

$AZN$PFE
Wire

Top Midday Decliners

Aimei Health Technology (AFJK) terminated its merger deal with United Hydrogen Group, effective immediately, as the companies failed to complete the transaction within the agreed timeframe, according to a statement Wednesday.Shares of Aimei sank 49% as intraday trading volume jumped to over 165,000 from a daily average of about 10,000.AstraZeneca (AZN) and its partner Ionis Pharmaceuticals (IONS) said Thursday that a phase 3 trial for eplontersen in people with transthyretin-mediated amyloid cardiomyopathy failed to meet the primary efficacy endpoint.Shares of Ionis sank 24% as intraday trading volume soared to about 14.5 million from a daily average of roughly 1.89 million.Rackspace Technology (RXT) said Thursday that it expects a wider Q2 adjusted loss from a year earlier and also lowered its full-year 2026 outlook.Shares plunged 29% as intraday trading volume surged to over 40.0 million from the stock's daily average of about 24.1 million.Price: $13.45, Change: $-13.24, Percent Change: -49.61%

$AFJK$AZN$IONS$RXT
Sectors

Sector Update: Healthcare Stocks Decline in Afternoon Trading

Healthcare stocks declined Thursday afternoon, with the NYSE Healthcare Index shedding 0.5% and the State Street Health Care Select Sector SPDR ETF (XLV) down 0.4%.The iShares Biotechnology ETF (IBB) was up 0.1%.In corporate news, AstraZeneca (AZN) and its partner Ionis Pharmaceuticals (IONS) said Thursday that a phase 3 trial for eplontersen in people with transthyretin-mediated amyloid cardiomyopathy did not meet the primary efficacy endpoint. AstraZeneca shares fell 5.4%, and Ionis tumbled 24%.Qiagen (QGEN) is attracting early takeover interest from private equity firms, including EQT AB, Advent and KKR (KKR), with some potential bidders considering offers of at least $50 per share, Bloomberg reported. Qiagen shares jumped past 10%.MetaVia (MTVA) shares rose 9% after it said Thursday that all active patients in part 3 of its phase 1 trial for obesity drug candidate DA-1726 have completed dose titration and reached their highest planned doses of 48 mg and 64 mg.

$AZN$IONS$MTVA$QGEN

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