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Immutep's Drug Candidate Now Has Clearer Potential Development Path, Jefferies Says

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Immutep's (ASX:IMM) eftilagimod alfa drug candidate, or efti, now has a clearer potential development path after the early termination of the TACTI-004 study, according to a Tuesday note by Jefferies.

Its root cause analysis increasingly supports TACTI-004 as a potentially isolated product-specific structural issue rather than a failure of efti's biology. The identification of subtle N-glycan differences in the efti material used in TACTI-004 is potentially important.

With prior efti data intact, head and neck squamous cell carcinoma prioritization, fast-track status, and planned manufacturing work, the risk and reward look more constructive despite residual execution risk.

The brokerage upgraded its rating on Immutep to buy from hold with the price target rising to AU$0.08 per share from AU$0.04.

What else is happening in Asia?

Asia

GenFleet Presents Updated Lung Cancer Therapy Data at Korean Medical Conference

GenFleet Therapeutics (HKG:2595) said Tuesday it presented the updated Phase 2 data for GFH375 monotherapy in pretreated KRAS G12D-mutant non-small cell lung cancer at the World Conference on Lung Cancer in South Korea.The company said the updated results showed an objective response rate of 59.2%, a disease control rate of 93%, and a 12-month overall survival rate of 77% in 71 subjects who received 600 milligrams of the oral drug, according to a Tuesday disclosure.

HKG:2595
Asia

White Cliff Minerals Says Gina Rinehart's Hancock Prospecting to Take 13.5% Stake With Nearly AU$9 Million Investment

White Cliff Minerals (ASX:WCN) said Hancock Prospecting agreed to acquire a 13.5% stake in the company through the purchase of about 515.8 million new shares at AU$0.017 each, representing a total investment of roughly AU$8.8 million, according to a Tuesday filing with the Australian bourse.Mining magnate Gina Rinehart is the executive chair of Hancock Prospecting.The private placement is subject to shareholder approval, which White Cliff Minerals will seek at an extraordinary general meeting planned for Oct. 19.If approval is obtained, the completion of the placement is expected three business days after the meeting, per the filing.White Cliff Minerals said it will use the proceeds to expand and fast-track drilling and exploration activities at its Rae copper project in Canada.

ASX:WCN
Asia

Wafangdian Bearing Seeks Delisting As Public Float Falls Below 10%

Wafangdian Bearing (SHE:200706) is looking to terminate its stock listing in Shenzhen following a tender offer, according to a Tuesday filing with the Shenzhen bourse.Up to 1,459 shareholders accepted the tender offer as of Feb. 27, 2026, the bearing manufacturer said in its filing.Following the tender offer, the public float fell to below 10%, falling short of the minimum float required to remain listed, Wafangdian said.

SHE:200706