NeuroSense Says Phase 2b Trial of PrimeC in Amyotrophic Lateral Sclerosis Meets Primary Endpoint
NeuroSense Therapeutics (NRSN) said Monday its phase 2b trial of its lead drug candidate PrimeC in amyotrophic lateral sclerosis met its primary efficacy endpoint, showing a "statistically significant" decrease in TDP-43 levels compared with placebo at day 180.The decrease in TDP-43, recognized as the pathological signature of ALS, gives biological evidence that PrimeC is engaging a core disease mechanism, the company said, adding that the reduction was sustained through 18 months.NeuroSense said that after obtaining US Food and Drug Administration clearance to start a global phase 3 trial, it is advancing trial preparations and engaging with regulators in several jurisdictions, including Canada.PrimeC is an oral formulation composed of FDA-approved ciprofloxacin and celecoxib.NeuroSense shares were up more than 8% in Monday trading.Price: $0.82, Change: $+0.06, Percent Change: +8.27%