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Sectors

Sector Update: Healthcare Stocks Advance Late Afternoon

Healthcare stocks were higher late Wednesday afternoon, with the NYSE Healthcare Index up 0.2% and the State Street Health Care Select Sector SPDR ETF (XLV) adding 0.3%.The iShares Biotechnology ETF (IBB) rose 0.5%.In corporate news, Merck (MRK) shares rose 2.4% after Daiwa upgraded the stock to outperform from neutral and raised its price target to $143 per share from $120.Cencora (COR) said that certain Walgreens volume that was being serviced by the company, separate from the prime vendor agreement, has started moving outside the company from July 1. Meanwhile, Cencora said its prime vendor agreement remains unchanged and accounts for the majority of its business with Walgreens. Cencora shares fell past 5%.Legend Biotech (LEGN) could see pressures from competition and recent leadership change, potentially weighing on Carvykti myeloma therapy strategy, Oppenheimer said. It downgraded Legend to perform from outperform. Shares fell 5.2%.Definium Therapeutics (DFTX) shares rose 5% after the firm said its phase 3 trial of DT120 orally disintegrating tablets in adults with generalized anxiety disorder met its primary endpoint.

$COR$DFTX$LEGN$MRK
Wire

Legend Biotech Shares Fall After Oppenheimer Downgrade

Legend Biotech (LEGN) shares were down 5.6% in Wednesday trading after Oppenheimer downgraded the company's stock to perform from outperform.Trading volume stood at about 2 million shares, compared with a daily average of roughly 2.7 million.Price: $20.59, Change: $-1.24, Percent Change: -5.68%

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Sectors

Sector Update: Healthcare Stocks Ease in Afternoon Trading

Healthcare stocks edged lower Wednesday afternoon, with the NYSE Healthcare Index and the State Street Health Care Select Sector SPDR ETF (XLV) each down 0.1%.The iShares Biotechnology ETF (IBB) rose 0.4%.In corporate news, Legend Biotech (LEGN) could see pressures from competition and its recent leadership change, potentially weighing on its Carvykti myeloma therapy strategy, Oppenheimer said in a note. The firm downgraded Legend to perform from outperform and cut the price target to $40 from $75. Legend shares fell nearly 6%.Arbutus Biopharma (ABUS) shares dropped 2.5% after the company reported that it swung to a Q2 loss as revenue fell during the period.Definium Therapeutics (DFTX) shares jumped 6% after it said Wednesday its phase 3 trial of DT120 lysergide orally disintegrating tablets in adults with generalized anxiety disorder met its primary endpoint.

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Wire

Legend Biotech Could See Pressures From Competition, CEO Transition, Oppenheimer Says

Legend Biotech (LEGN) could see pressures from competition and its recent leadership change, potentially weighing on its Carvykti myeloma therapy strategy, Oppenheimer said in a Wednesday note.Chief Executive Ying Huang resigned from the company in July and his departure raised concerns over strategies as Anito-cel nears potential approval and commercialization as a competing myeloma treatment, the investment firm said.Anito-cel's approval could pressure Legend Biotech's stock and Carvykti's near-term growth, but Oppenheimer noted that it continues to expect Carvykti to corner a majority of the market share in multiple myeloma.Carvykti sales could still peak at about $5 billion, but its near-term position could depend on the new CEO's strategic vision, the brokerage said.Oppenheimer downgraded Legend Biotech to perform from outperform and adjusted the price target to $40 from $75.Price: $20.66, Change: $-1.17, Percent Change: -5.36%

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Research

Oppenheimer Downgrades Legend Biotech to Perform From Outperform

Legend Biotech (LEGN) has an average rating of overweight and mean price target of $47.41, according to analysts polled by FactSet.

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Sectors

Sector Update: Healthcare Stocks Mixed Premarket Tuesday

Healthcare stocks were mixed premarket Tuesday, with the State Street Health Care Select Sector SPDR ETF (XLV) marginally declining and the iShares Biotechnology ETF (IBB) advancing by 0.3%.IDEXX Laboratories (IDXX) shares were up more than 3% after the company launched the Catalyst proBNP Test, a dual-species in-clinic test for NT-proBNP designed to help veterinarians assess heart disease in cats and dogs.Legend Biotech (LEGN) stock was up more than 4% after the company reported that it swung to Q2 earnings as revenue increased during the period.Cardinal Health (CAH) shares were up 0.9% after the company posted higher fiscal Q4 non-GAAP earnings and revenue.

$CAH$IBB$IDXX$LEGN$XLV
Commodities

Exchange-Traded Funds Higher, Equity Futures Mixed Pre-Bell Tuesday Amid Stalled US-Iran Talks

The broad market exchange-traded fund SPDR S&P 500 ETF Trust (SPY) was up 0.2% and the actively traded Invesco QQQ Trust (QQQ) was 0.4% higher in Tuesday's premarket activity as stalled US-Iran talks weigh on investors.US stock futures were mixed, with S&P 500 Index futures up 0.1%, Dow Jones Industrial Average futures slipping 0.03%, and Nasdaq futures gaining 0.3% before the start of regular trading.The National Federation of Independent Business' monthly Small Business Optimism Index rose to a reading of 99.8 in July from 97.4 in June but was below a reading of 100.3 a year earlier.The existing home sales data for July will be released at 10 am ET.In premarket action, bitcoin was up by 0.7%. Among cryptocurrency ETFs, the cryptocurrency fund ProShares Bitcoin Strategy ETF (BITO) was 0.8% higher, Ether ETF (EETH) advanced 0.9%, and Bitcoin & Ether Market Cap Weight ETF (BETH) gained 0.5%.Power Play:ConsumerThe State Street Consumer Staples Select Sector SPDR ETF (XLP) was down 0.02%, the Vanguard Consumer Staples Index Fund ETF Shares (VDC) was 0.7% lower, and the iShares US Consumer Staples ETF (IYK) was inactive. The State Street Consumer Discretionary Select Sector SPDR ETF (XLY) lost 0.02%. The VanEck Retail ETF (RTH) and the State Street SPDR S&P Retail ETF (XRT) were inactive.Upwork (UPWK) shares were down more than 18% pre-bell after the company posted Q3 and 2026 guidance that trailed analyst estimates.Winners and Losers:FinancialThe State Street Financial Select Sector SPDR ETF (XLF) advanced 0.03%. Direxion Daily Financial Bull 3X Shares (FAS) was down 0.01%, while its bearish counterpart, Direxion Daily Financial Bear 3X Shares (FAZ), was 0.03% lower.Riot Platforms (RIOT) shares were up 16%, a day after that company said that it signed a computing agreement expected to generate $9.10 billion in revenue over the initial 20-year term and includes two five-year extension options that could bring total contract value to $16.10 billion.IndustrialThe State Street Industrial Select Sector SPDR ETF (XLI) advanced 0.3%, the Vanguard Industrials Index Fund (VIS) was flat, and the iShares US Industrials ETF (IYJ) was inactive.Plug Power (PLUG) stock was up more than 14% before the opening bell after the company reported a narrowed Q2 adjusted net loss and higher revenue.Health CareThe State Street Health Care Select Sector SPDR ETF (XLV) retreated 0.01%, the Vanguard Health Care Index Fund (VHT) gained 0.01%, while the iShares US Healthcare ETF (IYH) was inactive. The iShares Biotechnology ETF (IBB) was 0.4% lower.Legend Biotech (LEGN) stock was up more than 4% premarket after the company reported forecast-beating Q2 earnings and revenue.EnergyThe iShares US Energy ETF (IYE) was up 0.1%, while the State Street Energy Select Sector SPDR ETF (XLE) was down by 0.2%.HighPeak Energy (HPK) stock was up more than 4% after the company reported higher Q2 earnings and revenue late Monday.TechnologyThe State Street Technology Select Sector SPDR ETF (XLK) advanced 0.6%, the iShares US Technology ETF (IYW) was flat, and the iShares Expanded Tech Sector ETF (IGM) was down 0.03%. Among semiconductor ETFs, the State Street SPDR S&P Semiconductor ETF (XSD) was 2.4% higher, while the iShares Semiconductor ETF (SOXX) rose by 1.4%.Nvidia (NVDA) shares were 1% higher pre-bell after the chipmaker said it partnered with six major financial institutions to raise $500 billion in third-party capital for the development of artificial intelligence infrastructure.CommoditiesFront-month US West Texas Intermediate crude oil advanced by 0.4% to $82.43 per barrel on the New York Mercantile Exchange. Natural gas was 0.04% lower at $2.79 per 1 million British Thermal Units. The United States Oil Fund (USO) increased by 0.1%, while the United States Natural Gas Fund (UNG) was 1% higher.Gold futures for November gained by 0.7% to reach $4,451.70 an ounce on the Comex. Silver futures retreated 0.2% to $65.18 an ounce. SPDR Gold Shares (GLD) was up by 0.2%, and the iShares Silver Trust (SLV) was 1.1% higher.

Dow JonesNasdaq CompositeS&P 500$BETH$BITO$EEM$EETH$EXI$FAS$FAZ$GLD$HPK$IBB$IGM$IGV$IPK$IVV$IWM$IYE$IYH$IYJ$IYK$IYW$LEGN$NVDA$PLUG$PMR$QQQ$RIOT$RTH$SLV$SOXX$SPY$UNG$UPWK$USO$VDC$VHT$VIS$XLE$XLF$XLI$XLK$XLP$XLV$XLY$XRT$XSD
Wire

Legend Biotech's In Vivo CAR-T Cell Therapy Data Validates Approach, RBC Capital Markets Says

Legend Biotech's (LEGN) data from its in vivo CAR-T cell therapy program clearly validates the approach, RBC Capital Markets said in a note Monday.The investment firm said the market is not fully appreciating Legend Biotech's potential with the program, with the company giving back most of its share gains.RBC said the potential for additional follow-up data this year and the fact that in vivo's profile should enable higher peak potential could drive Legend's shares higher.The company could reach the market as soon as 2029 if they move expediently with larger phase 1 dose expansion cohorts, enabling a $3 billion opportunity in non-Hodgkin lymphoma alone, according to the note.RBC Capital Markets retained an outperform rating on the stock, but lowered its price target to $59 from $63.Shares of the company were down more than 14% in Monday trading.Price: $18.97, Change: $-3.26, Percent Change: -14.65%

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Wire

Legend Biotech Shares Fall After UBS Downgrade

Legend Biotech (LEGN) shares were down 4.6% in Friday trading after UBS downgraded the company's stock to neutral from buy and adjusted its price target to $28 from $49.Trading volume stood at over 984,600 shares compared with a daily average of 2.6 million.Price: $22.45, Change: $-1.08, Percent Change: -4.59%

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Research

UBS Downgrades Legend Biotech to Neutral From Buy, Adjusts Price Target to $28 From $49

Legend Biotech (LEGN) has an average rating of overweight and mean price target of $53.73, according to analysts polled by FactSet.

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Commodities

Exchange-Traded Funds, Equity Futures Higher Pre-Bell Thursday as Interim US-Iran Deal Lifts Risk Sentiment

The broad market exchange-traded fund SPDR S&P 500 ETF Trust (SPY) was up 0.4%, and the actively traded Invesco QQQ Trust (QQQ) advanced 1.3% in Thursday's premarket activity, as investors welcomed an interim US-Iran agreement that reduced concerns about disruptions to global energy supplies.US stock futures were also higher, with S&P 500 Index futures up 0.7%, Dow Jones Industrial Average futures advancing 0.3%, and Nasdaq futures gaining 1.3% before the start of regular trading.US initial jobless claims fell to a level of 226,000 in the employment survey week ended June 13 from an upwardly revised 230,000 level in the previous week, compared with expectations for a larger decrease to 225,000 in a survey of analysts compiled by Bloomberg as of 7:30 am ET.The Philadelphia Federal Reserve's monthly manufacturing index rose to 10.3 in June after decreasing to minus 0.4 in May, compared with expectations for a slightly smaller increase to a reading of 10 in a survey compiled by Bloomberg.May's leading indicators data will be released at 10:00 am ET, followed by weekly natural gas stocks at 10:30 am ET.In premarket action, bitcoin was down by 0.6%. Among cryptocurrency ETFs, the cryptocurrency fund ProShares Bitcoin Strategy ETF (BITO) was 0.5% lower, Ether ETF (EETH) advanced 0.4%, and Bitcoin & Ether Market Cap Weight ETF (BETH) was flat.Power Play:FinancialThe State Street Financial Select Sector SPDR ETF (XLF) advanced 0.4%. Direxion Daily Financial Bull 3X Shares (FAS) was up 0.9%, while its bearish counterpart, Direxion Daily Financial Bear 3X Shares (FAZ), was 0.8% lower.HIVE Digital Technologies (HIVE) shares traded up 12% in early hours activity a day after the company said it received municipal approval to purchase the 32-megawatt Big Boden data center in Sweden from Bodens Utvecklings.Winners and Losers:Health CareThe State Street Health Care Select Sector SPDR ETF (XLV) advanced 0.2%, the Vanguard Health Care Index Fund (VHT) was down 0.1%, while the iShares US Healthcare ETF (IYH) gained 1.1%. The iShares Biotechnology ETF (IBB) was 0.1% higher.Legend Biotech (LEGN) stock was down more than 9% premarket after the company priced an underwritten public offering of 7.7 million American depositary shares at $29.35 each, for gross proceeds of about $226 million.TechnologyThe State Street Technology Select Sector SPDR ETF (XLK) gained 2%, and the iShares US Technology ETF (IYW) was flat, while the iShares Expanded Tech Sector ETF (IGM) was up 1.9%. Among semiconductor ETFs, the State Street SPDR S&P Semiconductor ETF (XSD) was 2.1% higher, while the iShares Semiconductor ETF (SOXX) rose by 4.2%.Intel (INTC) shares were up more than 9% in premarket activity after President Donald Trump said Apple (AAPL) has "agreed to work with Intel to design and build its Chips in America." Apple stock was gaining by 0.3%.EnergyThe iShares US Energy ETF (IYE) gained by 0.03%, while the State Street Energy Select Sector SPDR ETF (XLE) was down by 0.5%.Equinor (EQNR) stock was down more than 3% before market open after edging down 0.2% in the prior close. The company and its partners said they have selected the development concept for the Ringvei Vest project in the Norwegian North Sea, which is expected to contribute about 240 million barrels of oil equivalent.ConsumerThe State Street Consumer Staples Select Sector SPDR ETF (XLP) was up 0.3%, the Vanguard Consumer Staples Index Fund ETF Shares (VDC) was flat, and the iShares US Consumer Staples ETF (IYK) was inactive. The State Street Consumer Discretionary Select Sector SPDR ETF (XLY) gained 0.5%. The VanEck Retail ETF (RTH) was inactive, while the State Street SPDR S&P Retail ETF (XRT) rose 1%.Diageo (DEO) shares gained nearly 1% pre-bell after the Financial Times reported that Chief Executive Dave Lewis has ordered senior executives to implement broad cost-cutting measures as part of a major restructuring effort at the spirits giant.IndustrialThe State Street Industrial Select Sector SPDR ETF (XLI) advanced 1%, while the Vanguard Industrials Index Fund (VIS) was up 1.9% and the iShares US Industrials ETF (IYJ) was inactive.SpaceX (SPCX) stock was down more than 1% before the opening bell after experiencing its first post-IPO retreat from recent record highs, as market data and multiple analysts point to active put option trading and technical downward pressure following the stock's initial surge.CommoditiesFront-month US West Texas Intermediate crude oil retreated by 1.9% to $75.35 per barrel on the New York Mercantile Exchange. Natural gas gained by 0.5% to $3.16 per 1 million British Thermal Units. The United States Oil Fund (USO) declined by 1.2%, while the United States Natural Gas Fund (UNG) was 0.6% lower.Gold futures for July were down by 2.7% to $4,261.40 an ounce on the Comex. Silver futures retreated by 5.6% to $67.33 an ounce. SPDR Gold Shares (GLD) gained by 0.6%, and the iShares Silver Trust (SLV) was 0.02% lower.

Dow JonesNasdaq CompositeS&P 500$AAPL$BETH$BITO$DEO$EEM$EETH$EQNR$EXI$FAS$FAZ$GLD$HIVE$IBB$IGM$IGV$INTC$IPK$IVV$IWM$IYE$IYH$IYJ$IYK$IYW$LEGN$PMR$QQQ$RTH$SLV$SOXX$SPCX$SPY$UNG$USO$VDC$VHT$VIS$XLE$XLF$XLI$XLK$XLP$XLV$XLY$XRT$XSD
Wire

Legend Biotech Q1 Solid for Carvykti, Focus Shifts to In Vivo Pipeline, RBC Says

Legend Biotech (LEGN) reported a solid Q1 for Carvykti, while focus is increasingly shifting to in vivo pipeline programs with potential updates expected in the coming months and additional clinical progress through 2026, RBC Capital Markets said.The brokerage said in a note Tuesday that it was a "strong" quarter for Carvykti with 21% excluding-US and 8% US quarter-over-quarter growth to $597 million, driven by increasing use in earlier lines of therapy, expansion into community treatment centers, and limited competitive pressure.Investor focus is shifting to in vivo CAR-T programs, with the pipeline now including at least three assets targeting GPRC5D, BCMA, and CD19/CD20. The CD19/CD20 program is of particular interest, with an update expected around mid-2026 at a key medical meeting, and given that no abstract was included in the general release, it could potentially be presented as a late breaker in June, the analyst said."We see Carvykti as a best-in-class CAR-T therapy for multiple myeloma," the analyst said, adding that the therapy could reach $2.75 billion in 2026 sales and $8 billion at peak sales.The investment firm sees Legend Biotech on track toward adjusted company-wide profitability in 2026.RBC raised Legend Biotech's price target from $62 to $64, with an outperform rating.Price: $28.78, Change: $+0.52, Percent Change: +1.84%

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