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Surrozen Files Investigational New Drug Application for SZN-8141 in Diabetic Macular Edema

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Surrozen (SRZN) said Tuesday that it submitted an investigational new drug application to the US Food and Drug Administration seeking to evaluate SZN-8141 as a potential treatment for diabetic macular edema.

The company said it expects to launch a phase 1b/2a study in diabetic macular edema patients by the end of 2026, and anticipates initial data in H2 of 2027.

Surrozen said preclinical studies showed that SZN-8141 delivered "superior" biological activity in reducing neovascularization and promoting retinal revascularization in a rodent model of retinal vascular disease, compared with either Wnt agonist or anti-VEGF monotherapy.

SZN-8141 also demonstrated further reductions in vascular leakage than anti-VEGF therapy in a rodent model of neovascular age-related macular degeneration, the company said.

Shares of the company were down 2% in Tuesday trading.

Price: $22.31, Change: $-0.45, Percent Change: -1.98%

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