Novartis (NVS) discontinued development of VHB937 for amyotrophic lateral sclerosis, the company said in an emailed statement toWednesday.
The decision was taken after a phase 2 Astrals study did not meet its primary or secondary endpoints.
The company said it remains committed to sharing the study findings and applying the learnings from the research to advance scientific understanding of neurodegenerative diseases.
Price: $139.59, Change: $+0.97, Percent Change: +0.70%
Tempest Therapeutics (TPST) signed an exclusive option agreement with China's Hebei Senlang Biotechnology to license a clinical-stage technology that delivers CAR-T cancer treatments directly inside the body, along with a portfolio of related drug candidates.The portfolio includes an early-stage treatment that targets two proteins linked to multiple myeloma and is now being tested in a phase 1 study, Tempest said Tuesday in a statement. Other candidates in the group are aimed at blood cancers and autoimmune diseases, the company said.Tempest said it will continue to evaluate phase 1 results with Senlang during the option period.The company also disclosed in a regulatory filing that it raised about $2.5 million last week through a private placement of prefunded and common stock warrants.Tempest shares rose 35% in after-hours trading.
Top cryptocurrencies fell Tuesday, with Bitcoin (BTC-USD) dropping below $76,000.The CoinDesk Market Index, which tracks dozens of digital assets including Bitcoin, fell 5% in the past 24 hours. The Nasdaq 100 shed 0.8%, the S&P 500 lost 0.5%, and the Dow Jones Industrial Average declined 0.7%.Bitcoin fell 4.1% to $75,847, according to CoinMarketCap data. The most popular cryptocurrency's 24-hour trading volume rose 42% to $39.6 billion.Ethereum (ETH-USD), the second-largest digital asset by market value, declined 5.5% to $2,404.XRP (XRP-USD) lost 11%, BNB (BNB-USD) slumped 1.2%, and Solana (SOL-USD) shed 5.4%. Dogecoin (DOGE-USD) dropped 4.8%, and Cardano (ADA-USD) decreased 7.3%.The total market value of the cryptocurrency industry fell 4.1% in the past 24 hours to $2.58 trillion, with trading volume rising 31% to $103.1 billion.Price: $75891.45, Change: $-2289.88, Percent Change: -2.93%
(Updates with the latest stock price movement in the headline and the first paragraph.)PBF Energy (PBF) shares rose 6.1% on Tuesday, a day after the company said that, along with its PBF Finance unit, it priced $500 million worth of zero-rated exchangeable notes due 2032 in a private offering.The deal is expected to close on Sept. 17.PBF also granted the initial purchasers a 13-day option to buy up to an additional $50 million of notes, it said.The initial exchange rate is $96.80 per share, according to the company.Net proceeds, estimated at $485 million to $533.6 million, will be used to cover the cost of certain associated derivative transactions, repay other debt, and for general corporate purposes, PBF said.Price: $74.60, Change: $+4.20, Percent Change: +5.97%