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Mesoblast Achieves Patient Treatment Target in Phase 3 Trial of Chronic Lower Back Pain

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Mesoblast (ASX:MSB) achieved its target to treat at least 300 patients in a phase 3 trial of rexlemestrocel-L for chronic lower back pain linked to degenerative disc disease, according to a Tuesday filing with the Australian bourse.

The trial's primary endpoint targets a significant difference in the reduction of lower back pain between rexlemestrocel-L and sham controls after 12 months of treatment, while secondary endpoints include improvements in function, quality of life, and a halting of pain medications.

Rexlemestrocel-L obtained regenerative medicine advanced therapy designation from the US Food and Drug Administration, and the trial's topline results are due in mid-2027, the company said.

Mesoblast shares fell past 1% in recent Tuesday trade.

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