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Johnson & Johnson Says New Analysis of Ongoing Phase 3 Trial Data Supports Potential of Multiple Myeloma Combination Therapy

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Johnson & Johnson (JNJ) said Wednesday that new data from ongoing phase 3 MajesTEC-3 trial has demonstrated sustained disease control and survival rates for relapsed multiple myeloma patients receiving its dual-drug combination therapy.

Statistical models estimated that the regimen with TECVAYLI or teclistamab plus daratumumab extends median overall survival nearly four times longer than standard care options, the company said.

In an analysis, statistical modelling estimated that more than 85% of patients treated with the combination may have a mortality risk and projected life expectancy same as an age-matched general population, according to a statement.

The ongoing study showed approximately 83% of treated patients remained alive after three years while cutting the disease progression risk by 90% versus standard of care, the company added.

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KB Home Fiscal Q3 Earnings, Revenue Decline

KB Home (KBH) reported fiscal Q3 earnings late Tuesday of $1.05 per diluted share, down from $1.61 a year earlier.Analysts polled by FactSet expected $0.89.Revenue in the three months ended Aug. 31 fell to $1.3 billion from $1.62 billion a year earlier.Analysts projected $1.3 billion.The company expects Q4 housing revenue of $1.45 billion to $1.65 billion.KB Home projects full-year housing revenue of $4.9 billion to $5.1 billion, compared with the previous outlook of $4.9 billion and $5.3 billion.KB Home shares rose 1.6% in after-hours trading.

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Spire Global Wins $33.2 Million NOAA Contract for Satellite Weather Data

Spire Global (SPIR) won a $33.2 million contract from the National Oceanic and Atmospheric Administration to deliver global navigation satellite system radio occultation data to enhance weather forecasting.The data will feed NOAA's prediction models and support weather forecasting, space weather applications, and research by scientific organizations, Spire said Tuesday in a statement.The two-year contract, which starts Dec. 1, includes additional unfunded surge-buy options that may raise the total value to $66 million if fully exercised, the company said.Spire shares rose 2.2% in after-hours trading.

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Top Cryptocurrencies Mixed; Bitcoin Holds Above $86,000 Level

Top cryptocurrencies were mixed on Tuesday, with Bitcoin (BTC-USD) lower but holding above the $86,000 level.The CoinDesk Market Index, which tracks dozens of digital assets including Bitcoin, rose 1.1% in the past 24 hours. The Nasdaq 100 rose 0.9%, the S&P 500 added 0.1% and the Dow Jones Industrial Average decreased 0.2%.Bitcoin eased 0.2% to $86,307, according to CoinMarketCap data. The most popular cryptocurrency's 24-hour trading volume 18.2% to $42.71 billion.Ethereum (ETH-USD), the second-largest digital asset by market value, declined 0.4% to $2,751.XRP (XRP-USD) added 2.8%, BNB (BNB-USD) declined 1.6%, and Solana (SOL-USD) fell 1.0%. Dogecoin (DOGE-USD) lost 0.6%, and Cardano (ADA-USD) rose 1.7%.Total market value of the cryptocurrency industry rose 0.2% in the past 24 hours to $2.93 trillion, with trading volume dropping 15.4% to $117.38 billion.Price: $86317.84, Change: $-279.98, Percent Change: -0.32%

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