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EyePoint Misses Primary Goal in Phase 3 Wet AMD Trial of Duravyu; Shares Drop Pre-Bell

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EyePoint (EYPT) said Monday its Phase 3 Lugano trial testing Duravyu in patients with wet age-related macular degeneration failed to achieve its primary endpoint.

The drug missed the main visual acuity goal in the complete dataset because of a patient subgroup with vision loss unrelated to the condition, the company said.

However, Duravyu demonstrated non-inferiority to control treatment aflibercept in an ad hoc analysis that excluded those patients, EyePoint said.

The company said it expects topline data from a second Phase 3 trial in Q4 and foresees a potential regulatory submission in H1 2027.

Shares of the company fell more than 65% in recent premarket activity Monday.

Price: $5.14, Change: $-9.62, Percent Change: -65.19%

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