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European Markets Close Mostly Lower in Wednesday Trading Ahead of US-China Summit

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The European stock markets closed mostly lower in Wednesday trading as investors parsed US President Donald Trump's Tuesday night speech at the UN, and look ahead to the meeting between Trump and China President Xi Jinping.

The Stoxx Europe fell 0.3%, Germany's DAX lost 0.6%, France's CAC declined 0.3%, the Swiss Market Index dropped 0.2%, while the FTSE 100 edged 0.1% higher.

The seasonally adjusted S&P Global Flash Eurozone Composite PMI Output Index rose to 53.1 in September from 52.0 in August, marking the third straight month business activity has expanded in the eurozone and the fastest rate in more than three years.

"It's no surprise to see inflationary pressures on the rise again in September, given the increase in energy prices emanating from the ongoing conflict in the Middle East," Chris Williamson, chief business economist at S&P Global Market Intelligence, said. "But more encouraging is the resilience of economic growth being reported."

In corporate news, UBS was dealt a blow after the upper house of the Swiss parliament backed capitalization requirements largely in line with government demands, news outlets reported Wednesday.

Under the plan, the lender must back 90% of its foreign units with the highest-quality capital, a plan which UBS opposed, Bloomberg said. The bill must now be considered by the lower house of parliament. UBS Group said the decision would be "excessive" if confirmed at the conclusion of the ongoing parliamentary process.

"This political outcome is not a compromise and fails to address the root causes of the Credit Suisse collapse," UBS said. "It disregards the serious concerns expressed by the overwhelming majority of respondents in the democratic consultation process, which included all business representatives, the relevant employee associations and most cantons."

Shares of the Swiss lender dropped 1.4% in Zurich.

Novo Nordisk has won approval from Singapore authorities for the use of its weight-loss drug, Wegovy, to treat certain liver diseases, the drugmaker said Wednesday.

Wegovy, a once-weekly injectable semaglutide, can be prescribed to treat adult patients with non-cirrhotic metabolic dysfunction-associated steatohepatitis, or moderate to advanced liver fibrosis, as a complement to dieting and exercise, the company said.

The Singapore Health Sciences Authority approved Wegovy for treatment of fatty liver disease based on the interim week 72 efficacy analysis of a phase 3 trial, Novo said.

Shares of the Danish pharmaceutical company fell 2.5% in Copenhagen.

Ryanair will continue to cut flight frequencies in an effort to avoid exposure to unhedged fuel prices during the slow winter months, Bloomberg reported Wednesday.

Chief Executive Michael O'Leary told a press conference that the carrier might shift capacity to markets with lower fees such as Italy and Scandinavia, as he criticized the UK's "visitor taxes," saying the higher costs discouraged tourism and were "stupid and doomed to fail," Bloomberg reported.

Ryanair did not immediately respond to' request for comment.

Shares of the Irish airline lost 1.3% in Dublin.

TotalEnergies said it will develop the Ima gas field offshore Nigeria in partnership with AMNI.

TotalEnergies will hold a 40% stake in the shallow-water development, while the Nigerian enterprise AMNI owns the remaining 60%. No other terms were provided.

TotalEnergies said it expects the Ima field to start production in 2028, targeting a plateau of 350 million cubic feet per day, or 60,000 barrels of oil equivalent per day. The Ima field will feed gas through a pipeline to Nigeria LNG, a gas liquefaction facility 15% owned by TotalEnergies.

Shares of the French oil and gas company advanced 2% in Paris.

Diageo said it has named Joanne Wilson as its next chief financial officer, with Wilson expected to join the company and its board and succeed Nik Jhangiani in 2027.

Wilson currently serves as CFO of communications company WPP and previously held senior finance and commercial roles at Britvic, Dunnhumby, Tesco and KPMG, according to Diageo. Diageo said Jhangiani will remain with the company to help with the transition.

Shares of the alcoholic beverage company declined close to 1% in London.

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Update: US Equity Indexes Close Mixed While Treasury Yields Retreat With Crude Oil

(Updates with index/price moves and comments from the first paragraph.)US equity indexes ended mixed Tuesday, with materials emerging as top gainers while financials fronted the decliners.The Nasdaq Composite rose 0.5% to 27,244.28, after hitting an intraday record earlier in the session. The Dow Jones Industrial Average fell 0.4% to 51,863.69 while the S&P 500 was unchanged at 7,764.64.Energy and communication services were among the decliners, while the consumer staples sector was one of the biggest outperformers.On Monday, more US stocks in the S&P 500 index scored new 52-week lows during the session than notched 52-week highs, CNBC reported. The last time that occurred for the S&P 500 was in December 1999, the year before the dot.com bust, the news report said.US President Donald Trump told the UN General Assembly that a deal with Iran is possible after the midterm elections, but his other choice is to "annihilate the Islamic Republic," CNN reported.The key actors in the US-Iran war will be having meetings in New York, starting Tuesday, Thierry Wizman, global foreign-exchange and rates strategist at Macquarie, said in a note. "And the agreements and accords that come out of those meetings may determine whether the war continues and intensifies or whether an off-ramp is found.The front-month US West Texas Intermediate crude oil contract dropped 1.2% to $94.59 per barrel, while the global benchmark North Sea Brent slumped 1.6% to $98.69 per barrel.The Federal Reserve's next interest rate increase could come as early as October as higher oil prices threaten to push inflation farther away from the US central bank's 2% goal, Oxford Economics said in a report e-mailed Tuesday. The research outfit has raised its projections for oil prices, factoring in risks to oil shipments via the Red Sea at a time when the Strait of Hormuz remains effectively closed.The US Treasury's 2-year auction hit a high yield of 4.787% on Tuesday, up from the 4.204% high in the previous auction. The bid-to-cover ratio for the auction was 2.63, above the 2.60 ratio in the previous auction.Most US Treasury yields slipped, with the 10-year yield leaning lower to 4.96% and the two-year rate down by less than one basis point to 4.75%.Gold futures rose 0.3% to $4,397.5, and silver futures jumped 1.8% to $67.63, turning the corner from earlier in the day.In economic news, Redbook US same-store sales rose by 7.6% from a year earlier in the week ended Sept. 19 after an 8.5% year-over-year increase in the previous week.In company news, Amgen's (AMGN) phase 3 study of dazodalibep met its primary endpoint, showing statistically significant and clinically meaningful improvement in systemic disease activity at week 48 in adults with Sjogren's disease, the drugmaker said. Shares jumped 4.3%, the Dow's top gainer.

Dow JonesNasdaq CompositeS&P 500$AMGN
Asia Markets

Update: US Equity Indexes Mixed in Midday Trading

(Updates with index/price moves, macroeconomic data, and comments from the first paragraph.)US equity indexes were mixed, with materials emerging as top gainers while financials fronted decliners, in midday trading on Tuesday.The Nasdaq Composite edged up 0.3% to 27,211.5, after hitting an intraday record earlier in the session. The Dow Jones Industrial Average fell 0.4% to 51,821.2 while the S&P 500 was unchanged at 7,763.9. Financials and communication services led decliners.US President Donald Trump told the UN General Assembly that a deal with Iran is possible after the midterm elections, but his other choice is to "annihilate the Islamic Republic," CNN reported.The front-month US West Texas Intermediate crude oil contract climbed 0.5% to $96.30 per barrel, while the global benchmark North Sea Brent declined 0.3% to $100.05 per barrel.The Federal Reserve's next interest rate increase could come as early as October as higher oil prices threaten to push inflation farther away from the US central bank's 2% goal, Oxford Economics said in a report e-mailed Tuesday. The research outfit has raised its projections for oil prices, factoring in risks to oil shipments via the Red Sea at a time when the Strait of Hormuz remains effectively closed.The US Treasury's 2-year auction hit a high yield of 4.787% on Tuesday, up from the 4.204% high in the previous auction.The bid-to-cover ratio for the auction was 2.63, above the 2.60 ratio in the previous auction.Most US Treasury yields declined after midday, with the 10-year yield unchanged at 4.96% and the two-year rate less than one basis point to 4.75%.In economic news, Redbook US same-store sales rose by 7.6% from a year earlier in the week ended Sept. 19 after an 8.5% year-over-year increase in the previous week.The Richmond Fed's monthly manufacturing index fell to minus 2 in September from 4 in August, compared with the expectations for 2 in a survey compiled by Bloomberg.The Philadelphia Federal Reserve Bank's monthly non-manufacturing activity index worsened to minus 22.0 in September from minus 10.6 in the previous month, compared with the expectations for an improvement to minus 8.7 in a survey compiled by Bloomberg.In company news, Amgen's (AMGN) phase 3 study of dazodalibep met its primary endpoint, showing statistically significant and clinically meaningful improvement in systemic disease activity at week 48 in adults with Sjogren's disease, the drugmaker said. Shares jumped 3.9%, the Dow's top gainer.

Dow JonesNasdaq CompositeS&P 500$AMGN
Asia Markets

Exchange-Traded Funds Rise, US Equities Mixed After Midday

Broad Market IndicatorsBroad-market exchange-traded funds IWM and IVV edged higher. Actively traded Invesco QQQ Trust (QQQ) added 0.5%.US equity indexes traded mixed, with materials leading gainers and financials fronting decliners after midday on Tuesday.EnergyIShares US Energy ETF (IYE) fractionally up and the State Street Energy Select Sector SPDR (XLE) down less than 0.1%.TechnologyThe State Street Technology Select Sector SPDR ETF (XLK) added 0.4%; iShares US Technology ETF (IYW) rose 0.4%, and iShares Expanded Tech Sector ETF (IGM) gained 0.3%.The State Street SPDR S&P Semiconductor (XSD) was up 1.4%, and iShares Semiconductor (SOXX) rose 1.6%.FinancialThe State Street Financial Select Sector SPDR (XLF) was 1.8% lower. Direxion Daily Financial Bull 3X Shares (FAS) declined 5.5%, and its bearish counterpart, Direxion Daily Financial Bear 3X Shares (FAZ), advanced 5.6%.CommoditiesCrude added 0.5%, and the United States Oil Fund (USO) was down 0.9%. Natural gas gained 4%, and the United States Natural Gas Fund (UNG) moved 4.1% higher.Gold on Comex slipped 0.2%, and the State Street SPDR Gold Shares (GLD) was down 0.2%. Silver added 0.3%, and iShares Silver Trust (SLV) added 0.1%.ConsumerThe State Street Consumer Staples Select Sector SPDR (XLP) added 1.1% and the Vanguard Consumer Staples ETF (VDC) rose 1%.The State Street Consumer Discretionary Select Sector SPDR (XLY) was up 0.3%. VanEck Retail ETF (RTH) added 0.4%, and the State Street SPDR S&P Retail (XRT) rose 1.5%.HealthcareThe State Street Health Care Select Sector SPDR (XLV) gained 0.6%, while iShares US Healthcare (IYH) and Vanguard Health Care ETF (VHT) added 0.8% each. IShares Biotechnology ETF (IBB) was up 1.7%.IndustrialThe State Street Industrial Select Sector SPDR (XLI) fell fractionally. Vanguard Industrials Index Fund (VIS) was up 0.1% and iShares US Industrials (IYJ) dipped 0.1%.CryptocurrencyIn midday activity, bitcoin (BTC-USD) was fractionally lower. Among cryptocurrency ETFs, ProShares Bitcoin ETF (BITO) declined less than 0.1%, ProShares Ether ETF (EETH) was down 0.6%, and ProShares Bitcoin & Ether Market Cap Weight ETF (BETH) dropped 0.5%.

Dow Jones^EEM^EXI^FAS^FAZ^GLD^IBB^IGM^IGV^IPK^IVV^IWMNasdaq Composite^IYE^IYH^IYJ^IYK^IYW^PMR^QQQ^RTH^SOXXS&P 500^SPY^UNG^USO^VDC^VHT^VIS^XLE^XLF^XLI^XLK^XLP^XLV^XRT^XSD$BETH$BITO$EETH