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AbCellera Biologics' ABCL635 Meets Primary Efficacy Endpoints in Phase 2 Study

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AbCellera Biologics' (ABCL) ABCL635 met the primary efficacy endpoints in the Phase 2 portion of a Phase 1/2 study, significantly lowering the frequency and severity of moderate-to-severe hot flashes versus placebo, the company said Monday.

The company said a single subcutaneous 600 mg dose reduced daily hot flash frequency by 8.8 events at week four versus 3.5 with placebo, while symptom severity declined by 1.4 points versus 0.3, resulting in placebo-adjusted differences of 5.3 events and 1.1 points, respectively.

ABCL635 also improved sleep and patients' global impression of change and was well tolerated, with no serious or severe adverse events or treatment discontinuations reported during the four-week period, AbCellera added.

AbCellera Biologics shares were up 28% in premarket trading.

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GRAIL's Galleri Blood Test to Be Evaluated by US FDA Advisory Panel

GRAIL (GRAL) said Friday that an advisory panel of the US Food and Drug Administration will convene on Sept. 23 to evaluate the premarket approval application for its Galleri multi-cancer early detection blood test.The firm submitted the marketing application Jan. 29, incorporating trial results from 25,490 participants in its PATHFINDER 2 study along with over 70,000 subjects from its NHS-Galleri trial, the company said.Shares of the company were up about 8.9% in Friday trading.Price: $69.03, Change: $+5.63, Percent Change: +8.88%

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Top Cryptocurrencies Rise; Bitcoin Holds Above $64,000

Major digital assets rose Friday with Bitcoin (BTC-USD) still holding above $64,000.The CoinDesk Market Index, which tracks dozens of digital assets including Bitcoin, rose 0.3% in the past 24 hours. The Nasdaq 100 added 1.3%, the S&P 500 gained 0.6%, and the Dow Jones Industrial Average increased 0.2%.Bitcoin gained 0.9% to $64,938, according to CoinMarketCap data. The most popular cryptocurrency's 24-hour trading volume rose almost 11% to $21.65 billion.Ethereum (ETH-USD), the second-largest digital asset by market value, rose 0.6% to $1,918.XRP (XRP-USD) fell 1.1%, BNB (BNB-USD) increased 0.5%, and Solana (SOL-USD) rose 1.5%. Dogecoin (DOGE-USD) added 1.6%, while Cardano (ADA-USD) dropped 0.8%.The total market value of the cryptocurrency industry rose 0.6% in the past 24 hours to $2.21 trillion, with trading volume rising 5.3% to $55.6 billion.Price: $64913.74, Change: $+654.06, Percent Change: +1.02%

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Celestica Completes $3.45 Billion Equity Offering

Celestica (CLS) said Friday it completed a $3.45 billion equity offering through the sale of about 11.1 million common shares priced at $310 each.The offering comprised roughly 9.7 million common shares, with the underwriters fully exercising their option to purchase an additional 1.5 million shares.Celestica said it expects to use the net proceeds for working capital, investments in capital expenditures and other general corporate purposes.Price: $317.60, Change: $+3.07, Percent Change: +0.98%

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