-- 据周三提交给澳大利亚证券交易所的文件显示，PYC Therapeutics（ASX：PYC）已获得安全审查委员会的批准，可将候选药物PYC-001推进至针对常染色体显性遗传性视神经萎缩（ADOA）患者的多剂量递增研究。此前，该药物在60微克单次递增剂量试验中取得了积极的四周安全性和耐受性结果。 文件称，该公司目前正在评估ADOA患者的重复给药方案，以评估其安全性和初步疗效，旨在启动全球注册试验以支持新药申请之前，建立临床概念验证。 文件还补充道，正在进行的I期和II期多剂量递增研究的结果将于2026年和2027年陆续公布。 该公司股价在周三的交易中上涨了7%。
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Research Alert: CFRA Keeps Strong Buy Opinion On Shares Of Baker Hughes
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CFRA, an independent research provider, has providedwith the following research alert. Analysts at CFRA have summarized their opinion as follows:We lift our 12-month target to $285 from $275 following WAB's Q1 earnings print, valuing shares at 24.2x our 2027 EPS outlook of $11.76 (revised from $11.46; 2026 EPS estimate up to $10.57 from $10.50), a slight premium to WAB's long-term historical multiple average given structural improvements in earnings quality. While we are cautious on signs of overcapacity in the freight market, an elevated order backlog (12-month sits at over $9 billion), internal initiatives to shore up margins, and potential synergies from M&A activity positions WAB to continue growing earnings at double-digit rates in 2026-2027, in our view. Despite tariff-related cost pressures, WAB has done a commendable job of defending margins via a mix of pricing, lean manufacturing, and pruning of lower-profit operations. Q1 results were mixed but overall positive, in our view. We maintain our Hold recommendation on shares.
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