-- ピュアテック・ヘルス（PRTC）は水曜日、再発・難治性の高リスク骨髄異形成症候群および再発・難治性の急性骨髄性白血病の重度前治療患者を対象としたLYT-200の第1b相臨床試験の主要結果が、「強力な」抗白血病活性と「良好な」安全性プロファイルを示したと発表した。 同社によると、LYT-200と低メチル化剤の併用療法は、完全寛解、移植への橋渡し、および持続的な臨床効果をもたらした。 また、LYT-200は、試験したすべてのコホートおよび用量レベルにおいて一貫した安全性プロファイルを示したという。 同社によると、傘下のギャロップ・オンコロジー部門は、再発・難治性の高リスク骨髄異形成症候群を対象とした第2相臨床試験の推奨用量を決定し、試験デザインについて米国食品医薬品局（FDA）と協議する予定である。
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(Updates to add stock movement in the headline and last paragraph)Origin Energy (ASX:ORG) reported March quarter production of 164.5 petajoules, down from 167.1 petajoules a year earlier, according to a Monday filing with the Australian bourse.The company reported commodity revenue of AU$1.86 billion for the quarter, down from AU$ 2.31 billion a year ago, per the filing.Origin Energy also said its electricity sales volume increased 4% from a year earlier amid "strong growth" in business volumes driven largely by the data-center sector.The company's shares fell 3% in recent Monday trade.
Alterity Therapeutics (ASX:ATH) said it received positive feedback from a second type C meeting with the US Food and Drug Administration (FDA) on its planned phase three program for drug candidate ATH434, aimed at treating multiple system atrophy (MSA), according to a Monday filing with the Australian bourse.MSA is a progressive neurodegenerative disorder affecting autonomic and motor function with no approved disease-modifying therapies.The US FDA provided supportive written feedback on the program's chemistry, manufacturing, and controls, complementing earlier guidance from a separate type C meeting on clinical pharmacology and non-clinical development, the filing added.
Xinyuan Property Management Service's (HKG:1895) chief financial officer, Wang Yong, has resigned, effective April 26, according to a Monday Hong Kong bourse filing.Wang stepped down to devote more time to personal commitments, the company said.The company said the resignation will not affect its normal operations, with Wang's duties to be reallocated internally on an interim basis.Xinyuan Property Management added that it is seeking a suitable replacement for the chief financial officer role.