-- Arrowhead Pharmaceuticals (ARWR) 周二宣布，已与 Madrigal Pharmaceuticals (MDGL) 签署协议，获得其 ARO-PNPLA3 项目的独家授权。该项目正在评估一种治疗代谢功能障碍相关性脂肪性肝炎 (MASH) 的潜在疗法。 根据协议，Arrowhead 表示，Madrigal 将获得 ARO-PNPLA3 的全球许可，负责开发、生产和商业化。ARO-PNPLA3 利用 TRiM 平台抑制肝细胞中含有 patatin 样磷脂酶结构域 3 (PNPLA3) 的表达，有望成为 MASH 患者的潜在疗法。 Arrowhead 表示，交易完成后，将获得 2500 万美元的首付款，并有资格在达到开发、监管和销售里程碑后获得高达 9.75 亿美元的额外款项。 Arrowhead 还表示，其有资格获得商业销售额的分级特许权使用费，费率从个位数高位到十几位不等。
Price: $76.58, Change: $+0.19, Percent Change: +0.25%
US equity indexes rose in midday trading on Tuesday as crude oil futures slumped after Defense Secretary Pete Hegseth said the ceasefire agreement with Iran remains in force.The Nasdaq Composite traded 0.9% higher at 25,295.1, after touching a record 25,335.40 intraday. The S&P 500 climbed 0.7% to 7,252.3, and the Dow Jones Industrial Average advanced 0.5% to 49,187.7.Defense Secretary Pete Hegseth, speaking at a Tuesday morning press conference, said the Iran ceasefire remains in effect while promising to continue to press ahead with opening the Strait of Hormuz, the chokepoint for about a fifth of global crude oil flows.At the Pentagon press briefing, Gen. Dan Caine, chairman of the Joint Chiefs of Staff, said Iran's military actions didn't rise to the level of restarting the war, according to The Wall Street Journal. "No adversary should mistake our current restraint for a lack of resolve."The statements follow Tehran's strikes in the Strait of Hormuz and the United Arab Emirates on Monday, fueling concern that the Iran ceasefire was at risk of falling apart. Earlier this month, President Donald Trump told congressional leaders that "hostilities" with Iran have "terminated," addressing a critical 60-day deadline under a decades-old law meant to limit the use of military force without authorization from Congress, CBS News reported.West Texas Intermediate crude oil futures dropped 4% to $102.18, and Brent crude futures slumped 3.1% to $110.92.
Welltower (WELL) has an average rating of buy and mean price target of $234.16, according to analysts polled by FactSet.Price: $214.87, Change: $-2.27, Percent Change: -1.05%
The US Securities and Exchange Commission on Tuesday said it proposed rule and form amendments that would permit public companies to file semiannual reports in lieu of quarterly reports to meet their reporting obligations.Under the proposal, the filing deadline for semiannual reports would be 40 to 45 days, depending on the company's filer status, after the end of the first semiannual period of the fiscal year, the SEC said. The proposal will be published in the Federal Register, and the public comment period will remain open until 60 days after its publication, the agency said.