-- 独立研究机构CFRA向提供了以下研究报告。CFRA分析师总结如下：Alnylam公司公布了2026年第一季度的卓越业绩，季度产品收入首次突破10亿美元大关，创下公司23年发展历程中的历史新高。公司公布的非GAAP每股收益为2.05美元，高于去年同期的0.29美元，远超市场普遍预期的1.47美元。总收入达到11.67亿美元（同比增长96%），主要得益于净产品收入的强劲表现，达到10.36亿美元（同比增长121%）。TTR产品线继续保持强劲增长势头，收入达9.1亿美元（同比增长153%），其中AMVUTTRA贡献了8.9亿美元（同比增长187%），该疗法在美国上市一年后，依然保持着强劲的商业势头。 该公司重申了其 2026 年财务预期，预计总净产品收入为 49 亿美元至 53 亿美元，TTR 净产品收入为 44 亿美元至 47 亿美元。管理层强调了研发管线取得的重大进展，包括 nucresiran 的 TRITON-CM III 期研究的患者招募速度快于预期，预计将在 2026 年下半年公布多项临床结果。
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Oil & Energy
US Oil Update: Futures Tumble Amid Heightened US-Iran Tensions
Crude oil futures edged lower in midday trading on Thursday on reports that President Donald Trump would be briefed on expanded military options in Iran amid a deepening standoff between the US and Iran.Front-month West Texas Intermediate crude futures tumbled by 2.27% to $104.37 per barrel, while Brent futures dropped by 3.51% to $113.88/bbl.US crude exports surged last week as global buyers turned to American producers for alternative supplies amid the ongoing Middle East supply disruptions. The latest data from the Energy Information Administration shows that US crude stockpiles dropped by 6.2 million barrels to 459.5 mmbbls in the week ended April 24."This is a record high, surpassing the previous record of 5.63m b/d in February 2023," ING strategists said in a note Thursday, noting that these strong export volumes are increasingly tightening up the US domestic market.The inventories are now about 1% above the five-year average for this time of year, the EIA said.President Trump is reviewing new military options while maintaining a strict naval blockade on Iranian ports, signaling a hardline stance amid stalled negotiations.The US President is reportedly set to receive a briefing from the head of US Central Command, Admiral Brad Cooper, on plans for a series of new military strikes on Iran to force it to negotiate a deal to end the conflict.Iranian authorities, meanwhile, have vowed to respond with "long and painful strikes" on US positions if Washington renewed attacks, while reasserting control over the Strait of Hormuz.Iran Revolutionary Guards said that any new US military aggression would trigger previously undisclosed Iranian capabilities, including advanced smart targeting systems."You have seen the fate of your bases in the region; you will also see the fate of your warships", IRGC Aerospace Force Commander Majid Mousavi was quoted as saying.Iran's Supreme Leader, Mojtaba Khamenei, also said that Tehran would eliminate what he described as the enemy's abuse of the waterway under the new management of the strait, as his country moves to assert its control over the key chokepoint.On the supply front, the global oil market is undergoing a fragile rebalancing nearly two months after disruptions in the Hormuz slashed crude flows, with limited system flexibility keeping supplies tight.Data analytics firm Kpler said about 60 days into the disruption, oil flows through the key chokepoint remain close to minimal levels, falling from about 20 million barrels per day to about 1 million b/d in April.Traffic through the Hormuz remains limited and uneven, with crossings continuing to show a sharp directional imbalance, according to Kpler. As of April 29, a total of 12 vessel crossings were recorded, up by four day-on-day, with all ships moving west-to-east and no return traffic observed.
Australia
Market Chatter: Citigroup Pares Back Physical Trading in Industrial Metals
Citigroup (C) is stepping back from physical trading in industrial metals and has notified a number of staff from the commodities team about potential redundancies, Bloomberg reported Thursday, citing an employment tribunal in London.Citi said in a January letter that physical metals trading will no longer be a "core business activity," as the bank warned about 11 employees that they were at risk of redundancy and has let go a number of them since then, according to the report.Citi did not immediately respond to' request for comment.(Market Chatter news is derived from conversations with market professionals globally. This information is believed to be from reliable sources but may include rumor and speculation. Accuracy is not guaranteed.)Price: $128.19, Change: $+0.58, Percent Change: +0.45%
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Sectors
Update: Gold Rises as the Dollar and Yields Fall After a Report Showed U.S. Inflation Continues to Run Hot
(Updates prices.)Gold traded higher midafternoon Thursday as the dollar dropped after a report showed a key U.S. inflation measure rose last month while first-quarter gross domestic product rose less than expected.Gold for June delivery was last seen up US$71.30 to US$4,632.80 per ounce, remaining within the US$200 range it has traded within for the past month.The U.S. Bureau of Economic Analysis reported the March Personal Consumption Expenditures (PCE) Index, the Federal Reserve's preferred inflation measure, rose 0.7% in March from the prior month, up from 0.4% fin February, but matching expectations according to Marketwatch. Core PCE, excluding volatile food and energy, rose 3.2% annualized, up from 3.0% in February and again matching expectations.The bureau also issued its first estimate of first-quarter U.S. GDP growth, reporting the measure rose at a 2.0% pace, up from 0.5% in the prior quarter and under expectations for a 2.2% rise.Gold's gain comes despite expectations higher interest rates are on the way as the war on Iran pushes up inflation. The Federal Reserve's policy committee on Wednesday ended its two-day meeting on Wednesday leaving rates unchanged, but signaled hikes may be on the horizon as inflation climbs."Gold has attracted fresh demand despite rising bond yields and a firmer dollar following Wednesday's FOMC meeting, where rates were left unchanged, but several members signalled a desire to remove the easing bias as the Iran war continues to cloud the economic outlook," Saxo Bank wrote.Still, the dollar was sharply lower early following the economic data, with the ICE dollar index last seen down 0.81 points to 98.15. Treasury yields also fell, with the yield on the U.S. two-year note last seen down 7.1 basis points to 3.894%, while the 10-year note was paying 4.397%, down 3.7 points.
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